姓 名：忙定泽
职 称：教授/研究员，博士生导师
邮 箱：mangdz@163.com; mang@hbu.edu.cn
联系地址：河北省保定市五四东路180号，河北大学逸夫楼718室，
邮编：071002
Webpage in English：https://researchmap.jp/40896809?lang=en
【个人简介】
忙定泽，男，1988年11月生，博士，教授/研究员，博士研究生导师；河北省青年拔尖人才、省特聘专家，中国昆虫学会第十一届昆虫生理生化与分子生物学专委会青年委员。
主要从事生物化学与分子生物学的研究，聚焦于昆虫化感受体及营养代谢机制。作为课题负责人主持国家重点研发计划项目青年科学家课题，主持日本学术振兴会科学基金及河北省高层次人才项目等。在Insect Biochemistry and Molecular Biology，Journal of Agricultural and Food Chemistry，Pest Management Science，ACS Applied Materials & Interfaces, Chemical Communications等期刊发表论文30余篇。
已培养毕业硕士生3名（东京农工大学2名）、本科生4名；在读博士生1名，硕士生11名、在站博士后1名。
教育经历：
2013.03–2016.03 博士，东京农工大学
2012.04–2013.03 日本语学习，富士国际语学院早稻田校
2009.09–2012.07 硕士，贵州师范大学
2010.07–2012.04 联合培养硕士，中国科学院动物研究所
2005.09–2009.07 学士，贵州师范大学
工作经历：
2023.11至今 教授/研究员，博士生导师，河北大学
2023.06–2023.11 研究员（校聘），博士生导师，河北大学
2022.04–2023.06 研究员（校聘），硕士生导师，河北大学
2020.04–2022.03 Assistant Professor，东京农工大学
2016.06–2020.04 博士后，日本冲绳科学技术大学院大学
奖励荣誉：
2024.05 获河北省青年拔尖人才项目资助
2023.02 入选中国昆虫学会第十一届昆虫生理生化与分子生物学专委会青年委员
2018.12 获国际多肽研讨会“优秀发表奖”(日本 京都)
2016.03 东京农工大学优秀博士毕业生
2015.07 东京农工大学同窗会研究课外活动奖
2015.04 第四届国际(亚太)蚕业与昆虫生物技术大会获“杰出青年学者奖”(韩国 釜山)
2015.04–2016.03 国际Rotary米山纪念财团奖学金
2014.04–2015.03 东京农工大学(JIRITSU)研究奖励金
2013.04–2014.03 东京农工大学(JIRITSU)研究奖励金
2011.12 被评为“贵州师范大学2011–2012年度优秀研究生”
2010.10 获全国第三届大学生节能减排社会实践与科技竞赛“科信能环杯”三等奖
2010.07 获贵州省首届“硕博论坛”二等奖
杂志审稿人:
担任Journal of Natural Pesticide Research期刊编辑，Journal of Agricultural and Food Chemistry；Pest Management Science；International Journal of Molecular Sciences；Insects；Biomolecules；Frontiers in Physiology；Scientific Reports；Genes；Agronomy；Life；International Journal of Agricultural Science and Food Technology；The Journal of the Kansas Entomological Society等10余种SCI期刊独立审稿人。
小组成员：
学生获奖：
2023.11 崔哲博，获第六届全国入侵生物学大会“优秀墙报奖”，（中国，重庆）；
2023.10 孙静，获2023年研究生国家奖学金；
2023.08 孙静，获2023年国际昆虫学大会ICIS “优秀墙报奖”，（中国，河北）；
【科研领域】昆虫生态与分子生物学
主要从事生物化学与分子生物学的研究，聚焦于昆虫化学感受及营养代谢机制，主要以鳞翅目昆虫为研究对象，整合生理、生化、细胞、分子、遗传和组学研究方法和手段，在细胞、器官和个体水平上，对昆虫化学受体、内分泌及激素调控等方面进行研究。特别从“口器–脑–肠道”轴线出发，解析昆虫化感受体（如味觉受体，嗅觉受体等）在寄主植物叶片化学物质的感知和识别中的功能，以及食物摄入后如何继续感知营养物质，并将营养状态反馈到味觉系统，从而揭示其味觉/嗅觉系统的分子机制，以及味觉系统和消化系统的内分泌调节和肠道释放饥饿/饱腹感调节因子的分子机制。
【科研项目】
1. 2024/05-2027/04，河北省高层次人才（青年拔尖）资助项目“外来入侵害虫大规模群体形成与维持规律研究”，50万元，在研，项目负责人；
2. 2022/11-2025/10，国家重点研发计划“重大/新发入侵种大规模群体维持和灾变机理”项目青年科学家课题，338万元，在研，课题负责人；
3. 2021/04-2024/03，日本学术振兴会科学研究经费，Deciphering the Functions of Gustatory Receptors In the Recognition of Host Plant and Midgut Environment Using Knockout Silkworms，30万元，在研，主持；
4. 2020/04-2022/05，东京农工大学与美国Coteva Agriscience校企合作项目，Collaborative Research Project on Phage Display Technology，220万元，已结题，主持（日方项目负责人）.
【代表性论文】
（†共同第一作者, *通讯作者）
1. Sun J..† Zhang WJ.,†, Cui Z., Pan Y.., Guy S., Zhang L., Wickham J., Sun J.,* Mang D.,* 2024. HcGr76 responds to fructose and chlorogenic acid and involves in regulation of peptides expression in the midgut of Hyphantria cunea larvae. Pest Management Science. 79 (9): 3312-3325. (JCR一区，IF= 4.10)
2. Zhou Z., Mang D., Smagghe G., Liu Y., Mu Y., Yang L., Wang X., Chen X., 2024. A Farnesyl Pyrophosphate Synthase Gene Is Expressed in Fat Body Regulates Cantharidin Synthesis in Male Epicauta impressicornis Blister Beetle. Journal of Agricultural and Food Chemistry, 72 (23): 12935-12945. (JCR一区，IF= 5.895)
3. Mang D.,* Toyama, T., Yamagishi, T., Sun J., R. Purba E., Endo H., M. Matthews M., Ito K., Nagata N., Sato, R.,* 2023. Dietary compounds activate an insect gustatory receptor on enteroendocrine cells to elicit myosuppressin secretion. Insect Biochemistry and Molecular Biology. 155, 103927. (JCR 一区，IF=4.421).
4. Mang D.,†* Mayu K†, Toyama, T., Yamagishi, T., Sato, R.,* 2022. BmGr4 responds to sucrose and glucose and expresses in tachykinin-related peptide-secreting enteroendocrine cells. Insect Biochemistry and Molecular Biology. 150,103858. (JCR一区，IF=4.421).
5. Mang, D.,† Roy SR.,† Zhang Q.,† Hu, X., Zhang, Y., 2021. Heparan-Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration. ACS Applied Materials & Interfaces. 13, 15, 17236–17242. (JCR一区，IF= 10.383)
6. Mang, D.,† Zhang, S.,† Wu, X., Mochizuki T., Li G., Zhang, Y., 2019. Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect. Chemical Communications. 55, 6126–6129. (JCR一区，IF= 6.065).
7. Mang, D.,† Shu, M., † Tanaka, S., Nagata, S., Takada, T., Endo, H., Kikuta, S., Tabunoki, H., Iwabuchi, K., Sato, R., 2016. Expression of the fructose receptor BmGr9 and its involvement in the promotion of feeding, suggested by its co-expression with neuropeptide F1. Insect Biochemistry and Molecular Biology. 75, 58–69. (JCR一区，IF=4.421).
8. Mang, D., Shu, M., Endo, H., Yoshizawa, Y., Nagata, S., Kikuta, S., Sato, R., 2016. Expression of a sugar clade gustatory receptor, BmGr6, in the oral sensory organs, midgut, and central nervous system of larvae of the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology. 70, 85–98. (JCR一区，IF=4.421)
9. Mang, D.,† Sona R.,† Hong H. H., Wu, X., Zhang, J., Jin, C., Zhang, Y., 2020. Self-assembly of Integrin Ligands on Apical Membrane Inhibits the Migration of Glioma Cell. Langmuir. 36 (14): 3750–3757. (JCR二区，IF= 4.331)
10. Zhang, X.,† R. Purba, E.,† Sun, J.,† Zhang, Q., Dong, S., Zhang, Y., He, P., Mang, D.,* Zhang L.,* 2023. Functional differentiation of two general-odorant binding proteins in Hyphantria cunea (Drury). Pest Management Science. 79 (9): 3312-3325. (JCR一区，IF= 4.10)
11. Zhu, X., Xu, J., Li, L., Wang, D., Zhang, M., Yu, N., Purba, E. R., Zhang, F., Li, X., Zhang, Y*., Mang, D.,* 2020. Analysis of Chemosensory Genes in Semiothisa cinerearia Reveals Sex-Specific Contributions for Type-II Sex Pheromones Chemosensation. Genomics. 112 (6): 3846-3855. (JCR二区，IF= 4.301)
12. Wu, Z., Ye, J., Qian, J., Purba, E.R., Zhang, Q., Zhang, L.*, Mang, D.,* 2022. Identification and Expression Profile of Chemosensory Receptor Genes in Aromia bungii (Faldermann) Antennal Transcriptome. Insects.13, 96. https://doi.org/10.3390/insects13010096 (JCR二区，IF= 3.139).
13. Liu, D., Deng, J., Xu, W., Gu, T., Rinawati, P.E., Zhang, Q-H., Wickham, J.D., Mang, D.,* Zhang, L.,* 2022. Ultrastructureof Sensilla on the Antennae and Mouthparts of Hyphantria cunea Larvae. PeerJ. (JCR二区，IF=2.984).
14. Zhang, X.,† Mang, D.,† Liao, H., Ye, J., Qian, J., Dong, S., Zhang, Y., He, P., R. Purba, E., Zhang, L., 2020. Functional disparity of three pheromone-binding proteins to different sex pheromone components in Hyphantria cunea (Drury). Journal of Agricultural and Food Chemistry. 69, 55−66. (JCR一区，IF= 5.895)
15. Qian, J.,† Mang, D.,† Lv, G., Ye, J., L, Z., Chu, B., Sun, L., Liu, Y., Zhang, L., 2020.. Identification and Expression Profile of Olfactory Receptor Gene Based on Apriona germari (Hope) Antennal Transcriptome. Frontiers in Physiology. doi: 10.3389/fphys.2020.00807 (JCR二区，IF=4.755)
16. He, P.,† Mang, D.,† Wang, H., Wang, M., Ma, Y., Chen, G., Wang, J., Zhang, F., He. M., 2020. Molecular characterization and functional analysis of a Spodoptera exigua ubiquitous carboxylesterase suggested it acted as a cuticle enzyme degradation of ester chemical stimulus. Pesticide Biochemistry and Physiology. 163, 227–234. (JCR二区，IF= 4.966)
17. Ye, J.,† Mang, D.,† Ke, K., Cheng, C., Zhang, X., Tang, Y., Song. L., Zhang, Q., Zhang, L., 2021. Putative Carboxylesterase Gene Identification and Their Expression Patterns in Hyphantria cunea (Drury). PeerJ. e10919. (JCR二区，IF=2.984)
18. Endo, H., Tsuneto, K., Yamagishi, T., Mang, D., Ito, K., Nagata, S., Sato, R., 2022. Two gustatory receptors involved in host plant recognition of silkworm larvae. bioRxiv preprint doi: https://doi.org/10.1101/2022.09.12.507514.
19. Wang, Y., Adegawa, S., Miyamoto, K., Takasu, Y., Iizuka, T., Wada, S., Mang, D., S., Li, X., Kim, S., Sato, R., Watanabe, K., 2021. ATP-binding cassette transporter subfamily C members 2, 3 and cadherin protein are susceptibility-determining factors in Bombyx mori for multiple Bacillus thuringiensis Cry1 toxins. Insect Biochemistry and Molecular Biology. 139: 103649 (JCR一区，IF=4.421)
20. Shii, F., Mang, D., Dingze Mang, Kasubuchi, M., Tsuneto, K., Toyam, T., Sasaki, K., Endo, H., Sato, R., 2021. Ultrasensitive detection by maxillary palp neurons allows non-host recognition without consumption of harmful allelochemicals. Journal of Insect Physiology. 132: 104263. (JCR一区，IF=2.608)
21. Li G., Hu, X., Nie, P., Mang, D., Jiao, S, Zhang, S., Zhou, Y., Hoh, H., Roy, S., Yukawa, S., Asahina, S., Sugasawa, H., Cortes, W., Zhou, Z., Zhang, Y., 2021. Lipid-raft-targeted Molecular Self-assembly Inactivates YAP to Treat Ovarian Cancer. Nano Letetrs. 21, 747−755. (JCR一区，IF=12.262)
22. Li J., Chen Y., Wang Q., Yin M., Ma S., Liu Q., Sun X., Zhang W., Yang Y., Mang D., Zhu X., Sun L.,* Zhang Y.,* Gustatory Receptor 206 Participates in the Foraging Behavior of Larvae of Polyphagous Pest Spodoptera litura. Journal of Agricultural and Food Chemistry. 72, 21, 12003–12013. (JCR一区，IF= 5.895)
23. Zhang, Y., Zhang, X., Zhang, X., Xu, J., Li, L., Zhu, X., Wang, J., Wei, J., Mang, D., Zhang, F., Yuan, X., Wu, X., 2020. Key amino acid residues influencing binding affinities of pheromone binding protein from Athetis lepigone to two sex pheromones. Journal of Agricultural and Food Chemistry. 6092–6103. (JCR一区，IF=5.895)
24. Zhang, Y., Xu, J., Zhang, X., Zhang, X., Li, L., X., Yuan, Mang, D., Zhu, X., Zhang, F., Dewer, Y., Xu, L., Wu, X., 2020. Organophosphorus insecticide interacts with the pheromone-binding proteins of Athetis lepigone: implication for olfactory dysfunction. Journal of Hazardous Materials. 397, 122777. (JCR一区，IF=14.224)
25. Zhang, X., Yan, Q., Li, L., Xu, J., Mang, D., Wang, X., Hoh, H., Ye, J., Ju, Q., Ma, Y., Liang M., Zhang, Y., Zhu, X., Zhang, F., Dong, S., Zhang, Y., Zhang, L., 2020. Different binding properties of two general-odorant binding proteins in Athetis lepigone with sex pheromones, host plant volatiles and insecticides. Pesticide Biochemistry and Physiology. 164, 173–182. (JCR二区，IF= 4.966)
26. Zhang, S., Hu, X., Mang, D., Sasaki, T., Zhang, Y., 2019. Self-delivery of N-hydroxylethyl Peptide Assemblies to the Cytosol Inducing Cancer Cell Endoplasmic Reticulum Dilation. Chemical Communications. 55, 6126–6129. (JCR一区，IF= 6.065)
27. Du, E., Hu, X., Li, G., Zhang, S., Mang, D., Roy, S., Sasaki, T., Zhang, Y., 2018. Self-assembly-Directed Cancer Cell Membrane Insertion of Synthetic Ananlogues for Permeability Alteration. Langmuir, 35 (23), 7376-7382. (JCR二区，IF= 4.331)
28. Shu, M., Mang, D., Sunfu, G., Tanaka, S., Endo, H., Kikuta, S., Sato, R., 2016. Mechanisms of nodule-specific melanization in the hemocoel of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 70, 10–23. (JCR一区， IF=4.421)
29. 忙定泽，罗庆怀,舒敏,韦卫.长足大竹象成虫体表信息化学物质的提取和鉴定[J]. 昆虫学报. 2012,55 (3): 133-138.（中国科技核心期刊）
30. 忙定泽,罗庆怀,舒敏,孙翠英.中国豆野螟发生与防治研究沿革、进展及展望[J]. 中国农学通报.2012,28(4): 79-88.（中国科技核心期刊）
31. 刘丹,邓竣丹,许维康,顾天滋,忙定泽*,张龙娃*.美国白蛾触角感器的扫描电镜观察[J].植物保护学报.2023.（中国科技核心期刊）
32. 龙见坤,罗庆怀,忙定泽,石庆型,潘盛波.小型寄生蜂采集方法的简便有效改进及贵州稻田寄生蜂新记录[J]. 中国生物防治学报. 2010(S1). （中国科技核心期刊）
33. 潘盛波,罗庆怀,龙见坤,张志燕,忙定泽,舒敏.贵州发现黄杨绢野螟黑化个体及正常个体翅斑的变化[J]. 应用昆虫学报,2011,48(1):212-213. （中国科技核心期刊）
34. 龙见坤,罗庆怀,潘胜波,忙定泽,舒敏,张志燕.贵阳市金叶女贞上访花食蚜蝇物种多样性及其访花行为研究[J]. 环境昆虫学报,2010,32(2):235-242. （中国科技核心期刊）
35. 舒敏,张志燕,罗庆怀,王祖泽,忙定泽,朱小青,阎崇斌,贵州首次发现蔬菜检疫性害虫菜黑斯象及初步调查[J]. 长江蔬菜,2010,(11):45-46.
学术会议发表
1. Mang, D., Zhang, Y. Self-assembly of Integrin Ligands on Apical Membrane Inhibits the Migration of Glioma Cell. The 100th Annual Meeting of CSJ. Chiba, Japan, March 21–25, 2020. (Poster)
2. Mang, D., Sona R., Hong H. H., Wu, X., Li G., Hu, X., Zhang, Y. Laminin-derived peptide FFFYIGSR self-assembled to inhibit glioma cell migration and invasion. The 42nd Annual Meeting of the Molecular Biology Society of Japan (MBSJ). Fukuoka, Japan, December 3–6, 2019. (Poster).
3. Mang, D., Zhang, S., Wu, X., Mochizuki, T., Zhang, Y., Enzyme-mediated dual-targeted-assembly achieves synergetic anticancer effect. The 8th International Conference on Nanoscience and Technology. Beijing, China, August 16–19, 2019. (Poster)
4. Mang, D., Wu, X., Zhang, Y. Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect. The 98th Annual Meeting 2019 of CSJ. Kobe, Japan, March 16–19, 2018. (Oral)
5. Mang, D., Zhang, S., Wu, X., Zheng, Y., Zhang, Y. Enzyme-sorted-assembly of chiral peptides kills cancer cell via multi-subcellular targeting. 10th International Peptide Symposium Registration Confirmation. Kyoto, Japan, December 3–7, 2018. (Poster)
6. Mang, D., Morita, C., Shimomura, K., Tomita, N., Kikuta, S., Sato, R. Distribution of a gustatory receptor expressing cells in the midgut of the silkworm, Bombyx mori larvae. The 4th Asia-Pacific Congress of Sericulture and Insect Biotechnology. Abstract: 84, Busan, Korea, April 23–25, 2015. (Oral)
