【个人简介】

教育经历：

1998-2000博士后 美国加州大学河滨分校

1993-1996农学博士 中国农业大学

1984-1987农学硕士 河北农业大学

1980-1984农学学士 河北农业大学唐山分校

工作经历：

2010年—至今河北大学生命科学学院教授、博导

(2015.09—2016.02法国巴黎第六大学 高级研究学者)

2001年—2010年 美国华盛顿大学(西雅图)研究科学家

2000年—2001年韩国农业科学院访问科学家

1998年—2000年美国加州大学河滨分校博士后

1997年—1998年以色列本古里安大学访问科学家

1996年—1997年 中国农业科学院 博士后

1989年—1993年 河北科技师范学院 讲师

1987年—1989年 河北农业科学院棉花研究所 助研

奖励荣誉：

2018年获中国侨界贡献奖 二等奖

社会服务工作：十三届河北省人大代表、省人大教科文卫委员会委员、河北省侨联委员会委员、省侨联专家委员会委员、中国民主促进会河北省委委员；中国生物工程学会理事、河北省生物工程学会理事长、全国中西医结合学会嗅觉鼻颅底肿瘤专家委员会委员。

执教课程：课程名称本科生：蛋白质工程与酶工程；硕士生：蛋白质组学；博士生：表观遗传学。

【科研领域】

运用基因敲除小鼠、人源化基因敲入小鼠、RNA干扰、CRISPR/CAS9基因编辑脑部特定区域神经细胞等先进技术和手段，研究肥胖、嗅觉等疾病表型的表观遗传调控机理及其神经细胞发育机制。为肥胖、精神等相关疾病的治疗提供临床诊断依据和药物研发提供靶向位点。

【代表性论文】

1.Wang W, Dai X, Li Y, Li M, Chi Z, Hu X,Wang Z,* 2023，The miR-669a-5p/G3BP/HDAC6/AKAP12 Axis Regulates Primary Cilia Length.Advanced Science,e2305068.

2. Wu X, Yang D, Zhou Y, Li S,Wang Z,* 2022, The Role ofCiliopathy-associated Type 3 Adenylyl Cyclase in Infanticidal Behavior in Virgin Adult Male Mice.iScience 25，104534.

3. Yang D, Wu X, Wang W, Zhou Y,Wang Z,* 2022,Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy.Advanced Science,9(3):e2102568.

4. Chen T, Zhou Y, Liu X, Liu Y, Yuan J,Wang Z,* 2022,Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis. Theriogenology, 180:40-52.

5. Zhou K, Zhou Y, Yang D, Chen T, Liu X, Li S,Wang Z,* 2021, The Type 3 Adenylyl Cyclase is Crucial for Intestinal Mucosal Neural Network in the Gut Lamina Propria.Neurogastroenterology and Motility,33(9):e14140.

6. Yang D, Wu X, Zhou Y, Wang W, Wang Z,* 2020, The microRNA/TET3/REST axis is required for olfactory globose basal cell proliferation and male behavior.EMBO Reports,21(9):e49431.

7. Liu X, Zhou Y, Li S, Yang D, Jiao M, Liu X,Wang Z,* 2020,Type 3 adenylyl cyclase in the main olfactory epithelium participates in depression-like and anxiety-like behaviours.J Affect Disord, 268:28-38.

8. Liu X, Zhou Y, Yang D, Li S, Liu X,Wang Z,* 2020,Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice. Behav Brain Res, 383:112533.

9. Zhang Y, Zhao L, Fu S,Wang Z, Zhang J, 2020,Male pheromones and their reception by females are co-adapted to affect mating success in two subspecies of brown rats.Curr Zool, 67(4):371-382.

10.Zhang Z, Yang D, Zhang M, Zhu N, Zhou Y, Storm DR,Wang Z,* 2017,Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice. Front Cell Neurosci,11:1.

11. Wang Z,* Zhou Y, Luo Y, Zhang J, Zhai Y, Yang D, Zhang Z, Li Y, Storm DR, Ma RZ, 2015,Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice. Int J Mol Sci,16:28320-33.

12. Connelly T, Yu Y, Grosmaitre X, Wang J, Santarelli LC, Savigner A, Qiao X,Wang Z, Storm DR, Ma M, 2015,G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons.Proc Natl Acad Sci U S A,112:590-5.

13. Zou J, Pan YW,Wang Z, Chang SY, Wang W, Wang X, Tournier C, Storm DR, Xia Z, 2012,Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. J Neurosci,32:4118-32.

14. Wang Z,* Phan T, Storm DR, 2011,The type 3 adenylyl cyclase is required for novel object learning and extinction of contextual memory: role of cAMP signaling in primary cilia. J Neurosci,31:5557-61.

15. Wang Z,* Storm DR, 2011,Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclase. Neuropsychopharmacology,36:772-81.

16. Wang Z,* Li V, Chan GC, Phan T, Nudelman AS, Xia Z, Storm DR, 2009,Adult type 3 adenylyl cyclase-deficient mice are obese. PLoS One,4:e6979.

17. Wang Z,* Balet Sindreu C, Li V, Nudelman A, Chan GC, Storm DR, 2006,Pheromone detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium. J Neurosci,26:7375-9.

18. Wang Z,* Nudelman A, Storm DR, 2007,Are pheromones detected through the main olfactory epithelium? Mol Neurobiol,35:317-23.

19. Wang Z,* Miyake T, Edwards SV, Amemiya CT, 2006,Tuatara (Sphenodon) genomics: BAC library construction, sequence survey, and application to the DMRT gene family. J Hered,97(6):541-8.

20. Wang Z,* Storm DR, 2006, Extraction of DNA from mouse tails,Biotechniques,41(4):410,412.

21. Wang Z,* Farmer K, Hill GE, Edwards SV, 2006, A cDNA macroarray approach to parasite-induced gene expression changes in a songbird host: genetic response of house finches to experimental infection by Mycoplasma gallisepticum.Mol Ecol,15(5):1263-73.

22. Wang Z,* Baker AJ, Hill GE, Edwards SV, 2003,Reconciling actual and inferred population histories in the house finch (Carpodacus mexicanus) by AFLP analysis.Evolution, 57 (12):2852-64.

23. Lin CH, Hansen S,Wang Z, Storm DR, Tapscott SJ, Olson JM, 2005,The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Proc Natl Acad Sci U S A,102:14877-82.