【个人简介】
郭蕊，教授，博士生导师，河北省特聘专家, 河北省实验动物学会人类疾病动物模型专业委员会副主任委员，河北省生物工程学会理事，河北大学五四路校区实验动物中心负责人。中国细胞生物学学会会员，中国生物物理学学会会员。《医学研究与教育》青年编委，Frontiers in Physiology客座编辑，担任多个国际期刊的同行评委，以及多省市科技奖励评审专家。2017年国家优秀自费留学生奖学金获得者与发言人。2018年毕业于怀俄明大学（美）并获得生物医学哲学博士（Ph.D.）学位，有11年留美科研教学经历与实验室管理经验，同年12月全职引进河北大学生命科学学院。2019年与钟理教授共同组建了干细胞与生物医学研究实验室。2019-2024 年担任生物与医药研究生学位点负责人，学院学位评定分委会委员。2024年助力河北大学及河北省首个生物与医药专业博士学位授权点成功获批；协助申请并获批了保定市癌症与衰老研究重点实验室。
团队依托河北大学生物学博士点、生物与医药研究生专硕学位点、细胞生物学研究生学硕学位点以及河北省动物系统学与应用重点实验室、生物医药与疾病诊疗中心、实验动物中心等科研平台，围绕重大慢性疾病的发生发展机制与精准干预开展基础与转化研究，形成了较为完善的科研创新和人才培养体系。郭蕊课题组聚焦心脑血管疾病、糖尿病及其并发症、肿瘤心脏病学等领域，重点开展干细胞与组织损伤修复、工程化外泌体药物靶向递送与精准治疗、细胞基因靶向治疗以及创新药物研发等方向研究，致力于阐明疾病发生发展的分子机制，并推动科研成果向临床应用转化。至今在国际知名期刊Autophagy，Cardiovascular Research，European Heart Journal，Diabetes，Circulation，Cell Communication and Signaling，Cell death & Disease，Acta Physiologica等发表论文及国际顶会摘要60余篇，截止2026年9月，引用频次达2595以上，i10指数35。近几年先后主持国家自然科学基金、河北省自然科学基金、京津冀基础研究合作专项等多个项目。多次在AHA、ADA、EB、RACMEM国际顶会和国内重要会议中进行学术报告。
【执教课程】
• 生物工程专业外语（本科生，必修，2019-2021）• 细胞生物学（本科生，必修，2019-至今）• 细胞生物学实验（本科生，必修，2019-至今）• 研究生专业外语（研究生，必修，2019）
• 研究生专业英语与科技论文写作（研究生，必修，2020）• 研究生文献阅读-学术道德与论文写作（硕博研究生，必修，2024-至今）• 细胞生物学研究进展（研究生，必修，2019-至今）
• 生物医药技术与研究进展（研究生，专业选修，2019-至今）• 生命科学前沿研究（硕博研究生，必修，2019-至今）• 生物与医药实习实践课程（研究生，必修，2019-至今）。
【科研领域】
• 心脑血管等重大疾病的分子调控机制与靶向治疗
• 干细胞与细胞外囊泡在心血管等疾病中的研究与应用
• 干细胞定向分化与组织损伤修复
• 工程化外泌体药物靶向递送系统研究
• 肿瘤心脏病学与免疫代谢机制研究
• 糖尿病及其并发症分子机制及创新药物研发
• 大数据、人工智能与生物信息学
【荣誉奖励】
• 2017年度：国家优秀自费留学生获得者
• 2021.10：微课《普通光学显微镜的结构与使用》获得河北省教育教学信息化交流活动一等奖
• 2021.12：微课《普通光学显微镜的结构与使用》入选全国教师教育信息化交流活动高等教育组研讨作品
• 2022.6：2022届河北大学本科生毕业论文优秀指导奖
• 2022.8：指导全国大学生生命科学竞赛获得全国二等奖
• 2023.11：河北大学生命科学学院青年教师讲课大赛一等奖
• 2024.11：指导河北省大学生创新大赛银奖
• 2025年度：指导中国国际大学生创新大赛铜奖
此外，指导多名本硕学生发表高水平论文，并获国家奖学金、优秀毕业生及省优秀本科毕业论文等荣誉。
【研究团队】
干细胞与生物医学研究团队-干细胞与心血管代谢性疾病研究方向：郭蕊课题组是一支蒸蒸日上、充满科研激情与青春活力、流动着新鲜血液的科研队伍，是河北大学生命科学学院唯一一支以干细胞、心血管并发症以及细胞基因靶向药物研发为主要研究方向的科研队伍，每年在生物学博士点、细胞生物学（学硕）和生物与医药专业（专硕）招生，期待具有基础医学、药学、生理病理学、细胞工程、生物化学、细胞生物学、分子生物学、生物信息学等相关专业的优秀学子加盟，欢迎相关领域的博士后和青年人才加盟我们的团队。
【代表性论文】
1. Lei L, Wu S, Zhang L, Zhong L, Guo R*. Post-translational modifications of mitochondrion-related proteins: integrative orchestrators of cell fate networks in cardiovascular disease. Cell Communication and Signaling. 2026 Jun 13; 24:451.
2. Qin Q, Liu L, Fang Y, Zhang M, Liu X, Zhang R, Chen X, Zhong L, Guo R*. Cooperative action of cathepsin K inhibitor and hUMSC-EVs in attenuating ferroptosis sensitivity for superior diabetic wound healing. Diabetes. 2026 Apr; 75(6):1–17.
3. Yao H, Hao S, Chen X, Wu S, Yao X, Guo R*, Cui S. 偏振编码定量相位成像技术在心肌细胞动态特性研究中的应用.中国激光.Chinese Journal of Lasers. 2026 Jan; 53(3):0307110.2026 Jan; 53(3):0307110.
4. Cui L, Lyu T, Fu B, Wang Y, Qu Q, Wang F, Guo R*, Fan J, Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years. Theranostics. 2025 Aug; 15(18): 9508-9532. doi:10.7150/thno.120300.
5. Wang Y, Cui Y, Liu X, Liang S, Zhong L, Guo R*, Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis. Stem Cell Research & Therapy. 2025 Mar 5; 16(1):118.
6. Zhao M, Zhang R, Chen X, Li P, Yang H, Gao B, Li B, Zhou W, Wang Y, Zhang Y, Zhong L, Guo R*, TFEB activator protects against ethanol toxicity-induced cardiac injury by unblocking mitochondrial autophagic flux. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2025 Mar; 1871(3):167668.
7. Liu J#, Xu S#, Gao B, Yuan M, Zhong L, Guo R*, Protective effect of SERCA2a-SUMOylation by SUMO-1 on diabetes-induced atherosclerosis and aortic vascular injury. Molecular and Cellular Biochemistry. 2025 Jan; 480(1):279-293.
8. Zhou B#, Qin Q#, Fang Y#, Liu X, Zhang M, Wang S, Zhong L, Guo R*, Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis. Life Sciences. 2024 Dec 1; 358: 123108.
9. Zhang W, Uyemura R, Zhong K, Guo R*, Zhong L, Current Advances and Future Perspectives on Mesenchymal Stem Cell-Derived Extracellular Vesicles in Alzheimer's Disease. Aging and Disease. 2024 Oct 1; 15 (5):2015-2027.
10. Sun J, Zhong H, Kang B, Lum T, Liu D, Liang S, Hao J, Guo R*, Roles of PD-L1 in human adipose-derived mesenchymal stem cells under inflammatory microenvironment. Journal of Cellular Biochemistry. 2024 Apr; 125(4):e30544.
11. Gui M, Huang S, Li S, Chen Y, Cheng F, Liu Y, Wang J, Wang Y, Guo R, Lu Y, Cao P, Zhou G, Integrative single-cell transcriptomic analyses reveal the cellular ontological and functional heterogeneities of primary and metastatic liver tumors. Journal of Translational Medicine. 2024 Feb 27; 22(1):206.
12. Wang Y, Zhang H, Xu Z, Zhang S, Guo R, TransUFold: Unlocking the structural complexity of short and long RNA with pseudoknots, Mathematical Biosciences and Engineering. 2023; 31 (11):19320-19340.
13. Zhao M, Lian A, Zhong L, Guo R*, The regulatory mechanism between lysosomes and mitochondria in the aetiology of cardiovascular diseases. Acta Physiol (Oxf). 2022 Feb; 234(2):e13757.
14. Chen Y, Yang J, Wang Y, Shen W, Liu L, Yuan M, Hao X, Zhong L, Guo R*, Identification and Analysis of Hub Genes in Diabetic Cardiomyopathy: Potential Role of Cytochrome P450 1A1 in Mitochondrial Metabolism and STZ-Induced Myocardial Dysfunction. Frontiers in Cardiovascular Medicine. 2022 Mar; 21(9):835244.
15. Lochner A, Wang HH, Reiter R, Guo R, Zhou H, Editorial: Role of Mitochondrial Quality Control in Myocardial and Microvascular Physiology and Pathophysiology. Frontiers in Physiology. 2021 12: 745033.
16. Gu Z, Liang S, Liu D, Guo R, Zhong L, Novel development of mesenchymal stem cells-derived extracellular vesicles in regenerative medicine and disease therapeutics (in Chinese). Sci Sin Vitae [J]. 2021; 51(9): 1229-1240.
17. Li P, Zhong L, Guo R*, 重金属镉致心血管疾病的潜在机制及治疗对策.中国科学:生命科学. Sci Sin Vitae [J]. 2021; 51(9): 1241-1253.
18. Li Y, Zhao Q, Liang S, Zhong L, Guo R*, TFEB与线粒体稳态在脓毒症并发症中的调控机制. 中国科学:生命科学. Sci Sin Vitae [J]. 2021; 51 (9): 1208-1217.
19. Yang H, Heyer J, Zhao H, Liang S, Guo R*, Zhong L*, The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer. Molecules. 2020 Sep 10; 25(18):4136.
20. Guo R*, Yang H, Zhang Y, Li B, Liu X, Zhong L. The Potential Clinical Role of Cathepsin K and Autophagy in the Prevention of Alcoholic Cardiomyopathy. Circulation. 2019, 140 (Supplement 1): a15085.
21. Guo R, Wang Q, Nair R, Barnes S, Smith D, Dai B, Robinson T, Nair S: Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double blind clinical investigation. Functional Foods in Health and Disease. 2018; 8(11): 508-519.
22. Guo R, Hua Y, Ren J, Bornfeldt K, Nair S: Cardiomyocyte-Specific Disruption of Cathepsin K Protects Against Doxorubicin-Induced Cardiotoxicity. Cell death & disease. 2018; 9: 692.
23. Guo R, Ren J, Nair S. Cathepsin K Knockout Inhibits Calcification, Migration and Proliferation of Aortic Vascular Smooth Muscle Cells. American Heart Association (AHA) Scientific Sessions, 2017. POSTER presentation. Abstract: Circulation. June 2018; 136:A19464.
24. Guo R, Hua Y, Ren J, Bornfeldt K, Nair S. Cardiomyocyte-Specific Deletion of Cathepsin K Protects Against Doxorubicin-Induced Cardiac Dysfunction. American Heart Association (AHA) Scientific Sessions, New Orleans, LA, Nov. 12-16, 2016; POSTER presentation. Abstract: Circulation. March 2018, 134:A16698.
25. Guo R, Nair S. Role of MicroRNA in Diabetic Cardiomyopathy: from Mechanism to Intervention. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017; 1863(8):2070-2077.
26. Guo R, Hua Y, Rogers, O, Ren J, Nair S. Cathepsin K knockout preserves cardiac function in diabetic mice. Scientific Report. 2017 Aug; 7(1):8703.
27. Guo R, Rogers O, Nair S. Targeting Apelinergic System in Cardiometabolic Disease. Current drug targets. 2017; 18(15):1785-1791.
28. Guo R, Ren J, Nair S. Cathepsin K Knockout Inhibits Calcification, Migration and Proliferation of Aortic Vascular Smooth Muscle Cells. Circulation 2017, 136 (Supplement 1).
29. Guo R, Nair S, Ren J. Role of the Cathepsin K/Calcineurin/NFATs Axis in the Pathogenesis and Management of Diabetic Cardiomyopathy. Cardiology Plus. 2016; 1(3).
30. Guo R, Hua Y, Ren J, Bornfeldt K, Nair S. Cardiomyocyte-Specific Deletion of Cathepsin K Protects Against Doxorubicin-Induced Cardiac Dysfunction. Circulation. 2016, 134 (Supplement 1).
31. Guo R, Hua Y, Rogers O, Ren J, Nair S. Cathepsin K knockout Preserves Cardiac Function in Diabetic Mice: Role of Calcineurin/NFAT Signaling. Diabetes. 2016, 65 (Supplement 1): A101-A169.
32. Guo R, Zhang Y, Turdi S, Ren J: Adiponectin Knockout Accentuates High Fat Diet-Induced Obesity and Cardiac Dysfunction: Role of Autophagy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013; 1832(8):1136-1148.
33. Guo R, Hu N, Kandadi M, Ren J: Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine Hearts. Autophagy. 2012; 8(4):593-608.
34. Guo R, Ren J: Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation. Cardiovasc Res. 2012; 94(3):480-491.
35. Guo R, Ren J.Aldehyde Dehydrogenase-2 (ALDH2) Ameliorates Chronic Alcohol Ingestion-Induced Hepatic Steatosis and Inflammation. Experimental Biology Annual Scientific Meeting, San Diego Convention Center, San Diego, CA, Apr. 21-25, 2012; ORAL presentation. The FASEB Journal 2012, 26 (1), Supplement 405.8.
36. Ma H, Guo R, Yu L, Zhang Y, Ren J: Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J. 2011; 32(8):1025-1038.
37. Ge W, Guo R, Ren J: AMP-dependent kinase and autophagy are involved in aldehyde dehydrogenase 2-offered protection against cardiac toxicity of ethanol. Free Radic Biol Med. 2011; 51(9):1736-1748.
38. Guo R, Scott GI, Ren J: Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice. PLoS One. 2010; 5(6):e11268.
39. Guo R, Ren J: Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway. PLoS One. 2010; 5(1):e8757.
40. Guo R, Ren J: Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health. 2010; 7(4):1285-1301.
41. Guo R, Ma H, Gao F, Zhong L, Ren J: Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. J Mol Cell Cardiol. 2009; 47(2):228-237.
42. Guo R, Zhong L, Ren J: Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clin Exp Pharmacol Physiol. 2009; 36(5-6):463-468.
【书籍章节发表】
Guo R, Nair S. Protease Cathepsins in Cardiomyopathy: from Mechanism to Intervention. Proteases in human Diseases. p.447. Chapter 21. SpringerNature. 2017. DOI 10.1007/978-981-10-3162-5_21.
【教材出版】
《细胞生物学实验教程（第二版）》（ISBN：978-7-03-071320-9），科学出版社，2022.10.
【代表性科研项目】
1. 京津冀基础研究合作专项-河北省自然科学基金：靶向重编程外泌体技术在心肌炎性损伤修复中的应用研究，2023.12-2026-11，主持，在研。
2. 国家自然科学基金资助项目：Cathepsin K在糖尿病动脉粥样硬化发展中对SERCA2类泛素化修饰的调控机制，2022.01-2025.12，主持，已结题。
3. 国家自然科学基金青年项目：组织蛋白酶CTSK在酒精性心肌病中对自噬溶酶体途径调控机制的研究，2020.01-2022.12，主持，已结题。
4. 河北大学多学科交叉研究项目：定量相位成像技术在糖尿病心肌病病理机制研究中的应用2022.1-2024.12，主持，已结题。
