个人简介
张军，男，1986年04月生，河北保定人，博士，助理研究员/校聘副教授。主要从事合成生物学方面的教学和科研工作。主持和参加各类项目5项。在 Angewandte Chemie International Edition、Chemical Science 等国际学术期刊发表SCI论文 27篇，第一或通讯作者SCI论文 10篇。授权发明专利 5项，PCT 专利 2项。
教育经历：
2016.09-2019.06 北京大学生药学专业学习，获理学博士学位
2010.09-2013.06 河北大学植物学专业学习，获理学硕士学位
2006.09-2010.06 河北大学生物工程专业学习，获工学学士学位
工作经历：
2022.10-今 河北大学生命科学学院 助理研究员/校聘副教授
2019.07-2022.06 中国科学院微生物研究所 博士后（特别研究助理）
讲授主要课程
基因工程（本科生）
科研领域：
1.生物活性天然产物发现及生物合成途径解析
2.生物合成元件挖掘及人工生物合成途径构建
3.基于蛋白质工程的医药、农业和工业高附加值化学品绿色生物合成
承担科研项目
1.国家自然科学基金面上项目，32371553，2024.01-2027.12，50万，在研，主持；
2.河北省自然科学基金面上项目，B2023201103，2023.01-2025.12，8万，在研，主持；
3.国家重点研发计划，2018YFA0901602，2019.07-2024.06，50万，在研，骨干；
4.国家自然科学基金面上项目，32270094，2023.1-2026.12，54万，在研，参与；
5.京津冀基础研究合作专项项目，C2022201099，2022.10-2024.12，60万，在研，参与。
论文发表：
2023
27. Fangfang Zhu†,Jun Zhang†,*, Yaqing Ma, Lujia Yang, Qiang Gao*, Shushan Gao*, Chengsen Cui*. Semi-rational design of an imine reductase for asymmetric synthesis of alkylatedS-4-azepanamines.Organic Biomolecular Chemistry, 2023, 21, 4181-4184. (Co-first and corresponding author)
26.Jun Zhang†, Yaqing Ma†, Fangfang Zhu†, Jinping Bao, Qiaqing Wu, Shu-Shan Gao,* Chengsen Cui*. Structure-guide semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine.Chemical Science, 2023, 14, 4265-4272. (Outside back cover)
25. Zhuang Li, Bing-Wen Zhang, Li Jiang, He Wang, Qing-Yun Ma, Hong-Fei Wang,Jun Zhang, Feng-Li Chen, You-Xing Zhao*, Du-Qiang Luo*. Two new alkaloids from the endophytic fungusSchizophyllum sp. HM230 isolated fromVincetoxicum mongolicum Maxim.Natural Product Reaserch, 2023, online.
2022
24.Jun Zhang†, Xin Li†, Rongchang Chen†, Xianwei Tan, Xiongduo Liu, Yaqing Ma, Fangfang Zhu, Chunyan An, Guangzheng Wei, Yongpeng Yao, Lujia Yang, Peng Zhang, Qiaqing Wu, Zhoutong Sun, Bin-Gui Wang*, Shu-Shan Gao*, Chengsen Cui*. Actinomycetes-derived imine reductases with a preference towards bulky amine substrates. Communications Chemistry, 2022, 5, 123.
23.Jun Zhang†, Daohong Liao†, Rongchang Chen†, Fangfang Zhu, Yaqing Ma, Lei Gao, Ge Qu, Chengsen Cui, Zhoutong Sun*, Xiaoguang Lei*, Shu-Shan Gao*. Tuning an imine reductase for the asymmetric synthesis of azacycloalkylamines by concise structure-guided engineering.Angewandte Chemie International Edition, 2022, 61, e202201908.
22. Yongpeng Yao†, Wei Wang†, Wenyu Shi, Rui Yan,Jun Zhang, Guangzheng Wei, Ling Liu, Yongsheng Che, Chunyan An*, Shu-Shan Gao*. Overproduction of medicinal ergot alkaloids based on a fungal platform. Metabolic Engineering, 2022, 69, 198-208.
21. Chunyan An†, Fangfang Zhu†, Yongpeng Yao†, Kexin Zhang, Wei Wang,Jun Zhang, Guangzheng Wei, Yue Xia, Qiang Gao*, Shu-Shan Gao*. Beyond the cyclopropyl ring formation: fungal Aj_EasH is a promiscuous and bimodal dioxygenase that catalyzes asymmetric hydroxylation of ergot alkaloids.Applied microbiology and biotechnology, 2022,106, 2981-299.
2021
20. Guangzheng Wei†, Xian Shu†, Yongpeng Yao,Jun Zhang, Shu-Shan Gao*. Heterologous production of unnatural flavipucine family products provides insights into flavipucines biosynthesis.Organic Letters, 2021, 23, 7708-7712.
19. Xian Shu†, Guangzheng Wei†, Yuben Qiao†, Kexin Zhang,Jun Zhang, Guomin Ai, Mancheng Tang, Yonghui Zhang, Shu-Shan Gao*. TerC is a multifunctional and promiscuous FAD-dependent monooxygenase that catalyzes bimodal oxidative transformations.Organic Letters, 2021, 23, 8947-8951.
18. Jianhua Lv, Lan Yao, Jinxiu Zhang, Li-An Wang,Jun Zhang, Yingping Wang, Shengyuan Xiao, Changtian Li*, Yu Li*. New 2,5-diarycyclopentenones derivatives from the edible wild mushroomPaxillus involutus and their antioxidant activity.Journal of Agricultural food and chemistry, 2021, 69, 5040-5048.
17. Jianhua Lv, Lan Yao, Chao Duan, Zhuang Li,Jun Zhang, Changtian Li*, Yu Li*. New bioactive α-pyrone from wild mushroomPaxillus involutus. Natural Product Research, 2021, 34, 1246-1249.
2020
16.Jun Zhang, Lunyong Shi, Xu Yin, Fuchun Xu, Qingying Zhang, Peng-Fei Tu, Hong Liang*. Discovery of Novel Potential Plant Growth Regulators fromCorydalis mucronifera.Fitoterapia, 2020, 147, 104776.
15. Weiwei Liu, Chunyan An, Xiao Shu, Xiangxi Meng, Yongpeng Yao,Jun Zhang, Fusheng Chen, Hua Xiang, Shuyuan Yang, Xue Gao*, Shu-Shan Gao*. A dual-plasmid CRISPR/Cas system for mycotoxin elimination in polykaryotic industrial fungi.ACS Synthetic Biology, 2020, 9, 2087-2095.
14. Jinxiu Zhang, Jianhua Lv, Liqiang Zhao, Xiaoxi Shui,Jun Zhang, Li-An Wang*. Coumarin-pi, a new antioxidant coumarin derivative fromPaxillus involutus.Natural Product Research, 2020, 34, 1246-1249.
2019
13. Songleng Duan, Jun Zhang, Qinghua Han, Qingying Zhang, Hong Liang*. A new coumarin and a new norlignan fromFicus tsiangii. Journal of Asian natural products research, 2019, 21, 337-342.
12. Xuda Wang, Qinghua Han, Jun Zhang, Qingying Zhang, Peng-Fei Tu, Hong Liang*. Three new triterpenoid saponins fromAlbizia julibrissin,Journal of Asian Natural Products Research, 2019, 21, 535-541.
11. Wenbin Gao, Liping Han, Feixiang Xie, Qingyun Ma, Xiaofang Li,Jun Zhang, You-Xing Zhao*, Du-Qiang Luo*. A new polyketide-derived metabolite with PTP1B inhibitory activity from the endophytic fungusPestalotiopsis neglecta.Chemistry of Natural Compounds, 2019, 55, 1056-1058.
10. Wenbin Gao, Shasha Liu, Yingchao Tian, Qiang Dong, Jun Zhang, Jianchun Qin, Duqiang Luo*. Setosphaerine A, a New Chlorinated Polyketide Isolated from the Entomogenous FungusSetosphaeria rostrate.Natural Product Communications, 2019, 14, 1-3.
2018
9.Jun Zhang, Qingying Zhang, Pengfei Tu, Fuchun Xu*, and Hong Liang*. Mucroniferanines A-G, Isoquinoline Alkaloids fromCorydalis mucronifera.Journal of Natural Products, 2018, 81, 364-370.
8.Jun Zhang, Chen Zhang, Fuchun Xu, Quesheng, Qingying Zhang, Peng-Fei Tu, Hong Liang*.Cholinesterase inhibitory isoquinoline alkaloids fromCorydalis mucronifera.Phytochemistry, 2018, 159, 199-207.
7. Hengchun Ren,Jun Zhang, Hong Liang*. Two new p-coumaroylated sesquiterpenoids fromPilea cavaleriei.Journal of Asian natural products research, 2018, 20, 109-116.
6. Yi Liu,Jun Zhang, Ran Wen, Guangzhong Tu, Hubiao Chen, Hong Liang*, Yuying Zhao*. Anti-inflammatory and antiproliferative prenylated chalcones from Hedysarum gmelinii.Journal of Asian natural products research, 2018, 20, 1009-1018.
5. Zhong Wang, Peng Fan, Tongdan Xue, Linlin Meng, Wenbin Gao,Jun Zhang, Youxing Zhao*, Duqiang Luo*. Two new isocoumarin derivatives from an endophytic fungiOestalotiopsis coffeaeisolated from aMangrove fishtail palm.Natural Product Communications, 2018, 13, 57-59.
2013-2017
4.Jun Zhang, Linlin Meng, Jingjing Wei, Peng Fan, Shasha Liu, Weiyu Yuan, Youxing Zhao*, Duqiang Luo*. PTP1B inhibitors from the entomogenous fungiIsaria fumosorosea.Molecules, 2017, 22, 2058.
3.Jun Zhang, Shasha Liu, Weiyu Yuan, Jingjing Wei, Youxing Zhao*, Duqiang Luo*. Carotane-type sesquiterpenes from cultures of the insect pathogenic fungusIsaria fumosorosea.Journal of Asian Natural Products Research, 2017, 68, 1-7.
2. Linxia Liu†,Jun Zhang†, Chuan Chen, Jitao Teng, Chengshu Wang*, Duqiang Luo*. Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungusIsaria fumosorosea.Fungal Genetics and Biology, 2015, 81, 191-200. (Co-first author)
1. Duqiang Luo*, Yupeng Chen,Jun Zhang, Baozhong Shi, Ziqi Yang, Chuan Chen*. A new glycine derivative and a new indole alkaloid from the fermentation broth of the plant endophytic fungusPestalotiopsis podocarpi isolated from the Chinese podocarpaceae plantPodocarpus macrophyllus.Helvetica Chimica Acta. 2013, 96, 309-312.
专利和标准
6.罗都强, 文虹凯, 刘雨, 张军. 羊毛甾烷灵芝三萜类化合物的合成方法. 专利号: ZL 2023114312807.
5.高书山, 张军,崔成森, 马亚卿, 朱芳芳. 还原胺化酶突变体及其在烷基化吡咯烷手性胺合成中的应用.专利号: ZL 202310233977.7.
4.廖道红, 高书山, 雷晓光, 张军. 亚胺还原酶突变体M5及其在合成氮杂环手性胺中的应用. 专利号: ZL 202210294265.1.
3.高书山, 姚永鹏, 王伟, 安春艳, 张军, 颜芮. 菌株及其发酵生产麦角生物碱的应用. 专利号: ZL 202110898552.9.
2.罗都强, 张军, 刘智勤. 一种蛋白质络氨酸磷酸酶抑制剂、其制备方法及其用途.专利号: ZL 201210158554.5.
1. Du-Qiang Luo, Jun Zhang, Zhi-Qin Liu.Protein tyrosine phosphatase inhibitor, preparation method and uses thereof. PCT: US 9827232 B2/US 9849118 B2.
