个人简介

女，汉族，1981年出生，河北泊头人。理学博士，教授，博士生导师。

主要从事结构生物学研究，并结合生物化学、分子生物学以及细胞生物学等研究手段，着重开展人源DNA损伤修复、致病微生物关键代谢过程中重要蛋白的结构和功能研究。近年来，主持国家自然科学基金面上项目（32171295）和青年项目（31300056）、河北省自然科学基金青年项目（C2014201039）、河北省教育厅优秀青年基金项目（YQ2014007）、河北省教育厅重点项目（ZD2020183）及引进留学人员资助项目（ZD20200303）等。2015年度获得保定市科技进步一等奖。迄今为止，以第一或者通讯作者身份在Nature Communications、Nucleic acids Research、EMBO reports、Cancer Letters和Journal of biological chemistry等著名期刊发表20余篇高水平论文。其中，发表在Nature Communications上的论文被评为 “2019年中国百篇最具影响国际学术论文”。

教育经历：

2007.09-2011.06山东大学 微生物技术国家重点实验室生物化学与分子生物学专业 博士

2004.09-2007.06山东大学 微生物技术国家重点实验室 微生物学专业 硕士

2000.09-2004.06河北大学 生命科学学院 生物技术专业 本科

工作经历：

2011.06-2019.10河北大学 生命科学学院 副教授

2019.11-至今 河北大学 生命科学学院 教授

2019.01-2020.01美国希望之城国家医疗中心贝克曼研究所 访问学者

讲授主要课程

1. 《结构生物学》（本科生）

2. 《分子生物学》实验课（本科生）

3. 《结构生物学》（研究生）

承担科研项目

1. 国家自然科学基金面上项目《AI26抑制ARH3调控的DNA损伤修复的分子机制研究》（32171295），58万元，起止年限：2022.01-2025.12，项目负责人。

2.河北省自然科学基金面上项目《人源ARH3新型抑制剂的分子作用机研究》（C2022201025），10万元，起止年限：2022.01-2024.12，项目负责人。

3.河北省教育厅重点项目《铜绿假单胞菌中N-乙酰胞壁酸-6-磷酸酶MupP的结构与功能研究》（ZD2020183），9万元，起止年限：2020.01-2022.12。

4.教育部“春晖计划”合作项目《BARD1 BRCTs结构域与ADPR/PAR寡聚物复合物的结构与功能研究》，3万元，起止年限：2019.01-2021.12。

5.河北省教育厅优秀青年基金《大肠杆菌O157中肽聚糖水解酶MpaA的结构测定与功能研究》（YQ2014007），6万元，起止年限：2015.01-2017.12，项目负责人。

6.国家自然科学基金青年项目《大肠杆菌肽聚糖水解酶LdcA的结构与功能研究》（31300056），23万元，起止年限：2014.01-2016.12，项目负责人。

7. 河北省自然科学基金青年基金项目《大肠杆菌肽聚糖水解酶的结构与功能研究》（C2014201039），3万元，起止年限：2014.01-2016.12，项目负责人。

论文发表：（#第一作者，*通讯作者）

1.Yinliang Ma^#, Jiaxu Wang^#, Xingyi He, Yuhang Liu, Shuo Zhen,LiNa An, Qian Yang, Fumin Niu, Hong Wang, Boran An, Xinyue Tai, Zhenzhen Yan, Chen Wu*, Xiaoyun Yang*,Xiuhua Liu*.Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.Nucleic Acids Research.https://doi.org/10.1093/nar/gkad1210 (JCR一区, SCI, IF:14.9)

2. Xiaoyun Yang^#, Jiaxu Wang^#, Simin Li^#, Xiaobing Li, Jingjing Gong, Zhenzhen Yan, Huan Zhou, Chen Wu*,Xiuhua Liu*. Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.Nucleic Acids Research, 2023, 51(14): 7649–7665 (JCR一区, SCI, IF:14.9)

3.Hong Wang, Rong Xie, Fumin Niu, Qian Yang, Lina An, Chen Wu,*Xiuhua Liu,* and Xiaoyun Yang*.Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins.Structure, 2023, 31, 1578–1588. (JCR一区, SCI, IF:5.7)

4.Xiaorui Sun^#, Congwen Gao^#, Xin Xu, Mengyuan Li, Xinhua Zhao, Yanan Wang, Yun Wang, Shun Zhang, Zhenzhen Yan*,Xiuhua Liu*, Chen Wu^*. FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.EMBO Reports,2023,24(9):e56230. (JCR一区, SCI, IF:7.7)

5.Rong Xie, Zhenzhen Yan, Ju Jing, Yukun Wang, Jiajia Zhang, Yipeng Li,Xiuhua Liu*, Xiaochun Yu*, Chen Wu*.Functional defects of cancer-associated MDC1 mutations in DNA damage repair.DNA Repair, 2022,114:103330 (JCR二区, SCI, IF:3.927).

6. Yaqi Cui^#, Rong Xie, Xuefang Zhang, Yi Liu, Yixuan Hu, Yuan Li,Xiuhua Liu*, Xiaochun Yu* and Chen Wu*. OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.Cell Death and Disease, 2021, 12:622(JCR一区, SCI, IF: 9).

7.Lily Yu,Xiuhua Liu*, Xiaochun Yu*.ADP-ribosylhydrolases: from DNA damage repair to COVID-19. Journal of Zhejiang University-SCIENCE B. 2021,15,22(1):21-30. (JCR一区, SCI, IF:5.5)

8. Jiajia Zhang^#, Zhenzhen Yan^#, Yukun Wang, Yaguang Wang, Xin Guo, Ju Jing, Xiangnan Dong, Shasha Dong,Xiuhua Liu*, Xiaochun Yu*, Chen Wu*. Cancer-associated 53BP1 mutations induce DNA damage repair defects,Cancer Letters, 2021, 501: 43-54. (JCR一区，SCI，IF：6.786)

9. Xiuhua Liu^#, Rong Xie^#, Lily L. Yu^#, Shih-Hsun Chen^#, Xiaoyun Yang, Anup K. Singh, Hongzhi Li, Chen Wu, and Xiaochun Yu*. AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair,Journal of Biological Chemistry, 2020, 295(40): 13838–13849. (JCR二区，SCI, IF: 4.081)

10. Xiaoyun Yang^#, Yinliang Ma^#, Yimiao Li^#, Yating Dong^#, Lily L. Yu, Hong Wang,Lulin Guo, Chen Wu^*, Xiaochun Yu^*, Xiuhua Liu^*. Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation,DNA Repair, 2020, 94: 102899 (JCR二区, SCI, IF:3.927).

11. Jiaxu Wang^#, Zenglin Yuan^#, Yaqi Cui^#, Rong Xie, Guang Yang, Muzaffer A. Kassab, Mengxi Wang, Yinliang Ma, Chen Wu, Xiaochun Yu* andXiuhua Liu*.Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR,Nature Communications, 2018, 9: 2689. (Nature子刊, JCR一区, SCI, IF:11.878)

12. Mengxi Wang^#, Zenglin Yuan^#, Rong Xie^#, Yinliang Ma,Xiuhua Liu* and Xiaochun Yu*.Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation,Journal of Biological Chemistry, 2018, 293 (37): 14470-14480.(JCR二区，SCI, IF: 4.106)

13. Junqian Ma^#, Qian Dai, Xueyun Li, Xianghui Zhu, Teng Ma, Xiaoqiang Qiao*, Shigang Shen,Xiuhua Liu*. Dipentaerythritol penta-/hexa-acrylate based-highly cross-linked hybrid monolithic column: Preparation and its applications for ultrahigh efficiency separation of proteins.Analytica Chimica Acta. 2017, 963: 143-152. (JCR一区，SCI, IF: 5.123)

14. Xiuhua Liu^#*, Fei Gao^#, Yinliang Ma, Shuang Liu, Yaqi Cui, Zenglin Yuan, Xianjiang Kang*. Crystal structure and molecular mechanism of an aspartate/glutamate racemase from Escherichia coli O157,FEBS Letters, 2016, 590(8)：1262-1269. (JCR一区，SCI, IF: 3.623)

15. Xiuhua Liu^#*，Zenglin Yuan，Jiaxu Wang，Yaqi Cui，Shuang Liu，Yinliang Ma，Lichuan Gu，Sujuan Xu*. Crystal structure and biochemical features of dye-decolorizing peroxidase YfeX from Escherichia coli O157,Biochemical and Biophysical Research Communications，2017.01.19，484(1)：40~44.(JCR二区，SCI, IF: 2.559)

16.Yinliang Ma^#, Guohui Bai^#, Yaqi Cui, Jing Zhao，Zenglin Yuan,Xiuhua Liu*. Crystal Structure of Murein-Tripeptide Amidase MpaA from Escherichia coli O157 at 2.6Å Resolution,Protein & Peptide Letters, 2017, 24(2)：181-187.(SCI, IF: 1.039)

17. Guijun Shang^#,Xiuhua Liu^#, Defen Lu, Junbing Zhang, Ning Li, Chunyuan Zhu, Shiheng Liu, Qian Yu, Yanyu Zhao, Heqiao Zhang, Junqiang Hu, Huaixing Cang, Sujuan Xu, Lichuan Gu*. Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function.Biochem J, 2012, 448(2): 201-11.(JCR一区，SCI, IF: 4.654)

18.Xiuhua Liu^#, Qian Du, ZhiWang, Deyu Zhu, Yan Huang, Ning Li, TiandiWei, Sujuan Xu, Lichuan Gu*. Crystal structure and biochemical features of EfeB/YcdB from Escherichia coli O157: Asp235 plays divergent roles in different enzyme-catalyzed processes.J. Biol. Chem, 2011, 286: 14922-14931. (JCR一区，SCI, IF: 4.773)

19. Xiuhua Liu^#, Qian Du, Zhi Wang, Shiheng Liu, Ning Li, Ying Chen, Chunyuan Zhu, Deyu Zhu, Tiandi Wei, Yan Huang, Sujuan Xu, Lichuan Gu*. Crystal Structure of Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio cholerae at 1.7Å Resolution.FEBS Letters, 2012, 586 (8): 1240-1244. (JCR一区，SCI, IF: 3.582)

20. Xiuhua Liu^#, Jing Gong^#, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu and Lichuan Gu*. Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation.BMC Structural Biology, 2012, 12:23. (SCI, IF: 2.099)

21. Xiuhua Liu^#,Zhi Wang,Deyu Zhu,Tiandi Wei,Lichuan Gu,Sujuan Xu*. Crystallization and preliminary X-ray crystallographic studies of VibE, a vibriobactin-specific 2, 3-dihydroxybenzoate-AMP ligase fromVibrio cholerae. Acta Cryst. F. 2011,67: 1563-1565(SCI, IF: 0.506)

22. Chen Wu^#, Yaqi Cui^#,Xiuhua Liu, Feng Zhang, Lin-Yu Lu, Xiaochun Yu*.The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing, Journal of Molecular Cell Biology, 2020, 12(2):113-124. (SCI, JCR二区, 3年平均IF: 5.418)

23. Anup Kumar Singh^#, Bo Zhao^#,Xiuhua Liu, Xin Wang, Hongzhi Li, Hanjun Qin, Xiwei Wu, Yuelong Ma, David Horne, and Xiaochun Yu*.Selective targeting of TET catalytic domain promotes somatic cell reprogramming,Proc. Natl. Acad. Sci. USA, 2020, 117(7):3621-3626.(SCI, JCR一区, 3年平均IF: 9.582)

科研教学奖励

1. 霍乱弧菌中弧菌素合成酶VibF的A结构域基因的克隆、表达与纯化研究.2015年保定市科技进步一等奖，保定20154095-1号，第1完成人。