研究方向:
1.疱疹病毒1型(BoHV-1)潜伏感染和裂解性感染的分子机理和溶瘤分子机制;2. BoHV-1病毒诱导炎症反应发生的分子机理; 3. BoHV-1和牛病毒性腹泻病毒(BVDV)检测技术及疫苗。
主持的课题:
1. BoHV-1感染抑制53BP1依赖的对DNA损伤进行修复的分子机理研究, 国家
自然科学基金面上项目(No. 31972655), 2020/01- 2023/12,59万元(主持)
2. β-Catenin信号调节BoHV-1潜伏感染和裂解性感染的分子机理研究,国家自然科学基金面上项目(No. 31772743),2018/1-2021/12,59万元(主持)
3. PLC/钙离子信号在BoHV-1感染中的作用研究,国家自然科学基金面上项目(No.31472172),2015/01-2018/12,72万元(主持)
4. 科技部十三五国家重点研发专项“猪重要疫病抗原快速检测技术研究”子课题(No.2016YFD0500704)(牛病毒性腹泻病毒抗原诊断),2016-2020,30万元(主持)
5. HMGA1调节BoHV-1病毒感染的分子机制研究,农业部动物免疫学重点实验室/河南省动物免疫学重点实验室开放课题 (No. KLAI20170602), 2017/06 -2019/06, 10万元(主持)
6. BoHV-1潜伏感染模型的建立及β-catenin调节该病毒感染的分子机制 (C02220106),2022年河北省自然科学基金春晖人才计划: 2022/01/01-2024/01/01,10万元(主持)。
7. A549细胞产生的BoHV-1感染力下降的分子机制及其用于培育弱毒疫苗株的探索研究(C20220501),2022年河北省引进留学人员启动经费(优秀类),2022/09-2025/09,5万元(主持)
8. BoHV-1 gD 蛋白介导的溶瘤效应机制研究,2022年河北省自然科学基金(生物医药联合基金)(H2022201081),2022/01/01-2024/01/01,10万元(参与)。
以第一作者或通信作者发表SCI论文40余篇,部分论文如下:
1. Xiuyan Ding, Shitao Li, Liqian Zhu*, Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: a promising therapeutic target for virus infection-induced inflammatory diseases. Cytokine & Growth Factor Reviews. 2021, 62:54-61.
2. Ding X, Neumann DM*, Zhu L*. Host factors associated with either VP16 or VP16-induced complex differentially affect HSV-1 lytic infection. Rev Med Virol. 2022, 7: e2394.
3. Xinye Chen(#), Xiuyan Ding(#), Liqian Zhu*, GaipingZhang*. The identification of a B-cell epitope in bovine viral diarrhea virus (BVDV) core protein based on a mimotope obtained from a phage-displayed peptide library. Int J Biol Macromol. 2021, 183: 2376-2386
4. Wenqing Fan, Weifeng Yuan, Xiuyan Ding, Liqian Zhu*. β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture. Virulence. 2021, 12(1):1345-1361
5. Xiaotian Fu (#), Dongmei Chen (#), Yan Ma, Weifeng Yuan, and Liqian Zhu*. Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches. Oxidative Medicine and Cellular Longevity. 2019, 4957878.
6. Aspen Workman(#), Liqian Zhu(#), Brittany Keel, Timothy Smith, and Clinton Jones*. The Wnt signaling pathway is differentially expressed during the bovine herpesvirus 1 latency-reactivation cycle: evidence that two protein kinases associated with neuronal survival (Akt3 and bone morphogenetic protein receptor 2) are expressed at higher levels during latency. J Virol. 2018, 14;92(7). (co-first author)
7. Zhu L, Workman A, Jones C. A potential role for a β-catenin coactivator (high mobility group AT-hook 1 protein) during the latency-reactivation cycle of bovine herpesvirus 1. J Virol. 2017 Feb 14;91(5)
8. Zhu L, Thunuguntla P, Liu Y, Hancock M, Jones C. The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection. Virology. 2017. 500:91-95.
9. Liqian Zhu, Jessie Thompson, Fangrui Ma, James Eudy, Clinton Jones. Effects of the synthetic corticosteroid dexamethasone on bovine herpesvirus 1 productive infection. Virology. 2017. 505:71-79.
10. Liqian Zhu(#), Chen Yuan(#), Xiuyan Ding, Shuai Xu, Yuying Liang *, Qiyun Zhu*, PLC- gamma1 is involved in the inflammatory response induced by influenza A virus H1N1 infection, Virology, 2016, 496:131–137.
11. Liqian Zhu, Yuying Liang*, Hinh Ly, PLCgamma1 signaling plays a subtype-specific role in post-binding cell entry of Influenza A virus. J Virol. 2014, 88(1):417-24.
授权专利:
牛病毒性腹泻病毒抗体检测试纸及其制备方法.发明专利, 2018, 专利申请号:201810604281.X,(联合申请,第二申请人)已授权。