朱礼倩

职称:教授

邮箱:lzhu3596@163.com

地址:河北大学生命科学学院综合科研楼

  • 个人简介

工作经历

2022/11- 今:河北大学生命科学学院,教授,博士生导师

2021/11- 2022/11:河北大学生命科学学院,校特聘教授,博士研究生导师。

2015/11- 2020/10University of Wisconsin-Madison 助理教授

2012/5- 2015/10University of Minnesota, twin cities 博士后

执教课程:

《免疫学》(本科生)

《生物医药技术研究进展》(研究生)

研究生招生:

硕士研究生招生专业:071005 微生物学-分子病毒学方向(05)

博士研究生招生专业:071000生物学-微生物学方向(03)

团队建设:

欢迎具有预防兽医学、病毒学、肿瘤治疗和纳米药物等相关研究背景的青年教师和博士后加入实验室,联系方式:lzhu3596@163.com



研究方向:

1.疱疹病毒1型(BoHV-1)潜伏感染和裂解性感染的分子机理和溶瘤分子机制2. BoHV-1病毒诱导炎症反应发生的分子机理; 3. BoHV-1牛病毒性腹泻病毒(BVDV)检测技术及疫苗。

主持课题:

1. BoHV-1感染抑制53BP1依赖的对DNA损伤进行修复的分子机理研究, 国家

自然科学基金面上项目(No. 31972655), 2020/01- 2023/1259万元(主持)

2. β-Catenin信号调节BoHV-1潜伏感染和裂解性感染的分子机理研究,国家自然科学基金面上项目(No. 31772743),2018/1-2021/1259万元(主持)

3. PLC/钙离子信号在BoHV-1感染中的作用研究,国家自然科学基金面上项目(No.31472172),2015/01-2018/1272万元(主持)

4. 科技部十三五国家重点研发专项猪重要疫病抗原快速检测技术研究子课题(No.2016YFD0500704(牛病毒性腹泻病毒抗原诊断)2016-202030万元(主持)

5. HMGA1调节BoHV-1病毒感染的分子机制研究,农业部动物免疫学重点实验室/河南省动物免疫学重点实验室开放课题 (No. KLAI20170602, 2017/06 -2019/06, 10万元(主持)

6. BoHV-1潜伏感染模型的建立及β-catenin调节该病毒感染的分子机制 (C02220106),2022年河北省自然科学基金春晖人才计划: 2022/01/01-2024/01/0110万元(主持)。

7. A549细胞产生的BoHV-1感染力下降的分子机制及其用于培育弱毒疫苗株的探索研究(C20220501),2022年河北省引进留学人员启动经费(优秀类),2022/09-2025/09,5万元(主持)

8. BoHV-1 gD 蛋白介导的溶瘤效应机制研究2022年河北省自然科学基金(生物医药联合基金)(H2022201081)2022/01/01-2024/01/01,10万元(参与)。





以第一作者或通信作者发表SCI论文40余篇,部分论文如下:

1. Xiuyan Ding, Shitao Li, Liqian Zhu*, Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: a promising therapeutic target for virus infection-induced inflammatory diseases. Cytokine & Growth Factor Reviews. 2021, 62:54-61.

2. Ding X, Neumann DM*, Zhu L*. Host factors associated with either VP16 or VP16-induced complex differentially affect HSV-1 lytic infection. Rev Med Virol. 2022, 7: e2394.

3. Xinye Chen(#), Xiuyan Ding(#), Liqian Zhu*, GaipingZhang*. The identification of a B-cell epitope in bovine viral diarrhea virus (BVDV) core protein based on a mimotope obtained from a phage-displayed peptide library. Int J Biol Macromol. 2021, 183: 2376-2386

4. Wenqing Fan, Weifeng Yuan, Xiuyan Ding, Liqian Zhu*. β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture. Virulence. 2021, 12(1):1345-1361

5. Xiaotian Fu (#), Dongmei Chen (#), Yan Ma, Weifeng Yuan, and Liqian Zhu*. Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches. Oxidative Medicine and Cellular Longevity. 2019, 4957878.

6. Aspen Workman(#), Liqian Zhu(#), Brittany Keel, Timothy Smith, and Clinton Jones*. The Wnt signaling pathway is differentially expressed during the bovine herpesvirus 1 latency-reactivation cycle: evidence that two protein kinases associated with neuronal survival (Akt3 and bone morphogenetic protein receptor 2) are expressed at higher levels during latency. J Virol. 2018, 14;92(7). (co-first author)

7. Zhu L, Workman A, Jones C. A potential role for a β-catenin coactivator (high mobility group AT-hook 1 protein) during the latency-reactivation cycle of bovine herpesvirus 1. J Virol. 2017 Feb 14;91(5)

8. Zhu L, Thunuguntla P, Liu Y, Hancock M, Jones C. The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection. Virology. 2017. 500:91-95.

9. Liqian Zhu, Jessie Thompson, Fangrui Ma, James Eudy, Clinton Jones. Effects of the synthetic corticosteroid dexamethasone on bovine herpesvirus 1 productive infection. Virology. 2017. 505:71-79.

10. Liqian Zhu(#), Chen Yuan(#), Xiuyan Ding, Shuai Xu, Yuying Liang *, Qiyun Zhu*, PLC- gamma1 is involved in the inflammatory response induced by influenza A virus H1N1 infection, Virology, 2016, 496:131–137.

11. Liqian Zhu, Yuying Liang*, Hinh Ly, PLCgamma1 signaling plays a subtype-specific role in post-binding cell entry of Influenza A virus. J Virol. 2014, 88(1):417-24.

授权专利:

牛病毒性腹泻病毒抗体检测试纸及其制备方法.发明专利, 2018, 专利申请号:201810604281.X,(联合申请,第二申请人)已授权。




书记信箱

院长信箱 jiangyon...

图书馆

教务系统

办公系统

诚聘英才